Вестник МГТУ, 2025, Т. 28, № 2.

Вестник МГТУ. 2025. Т. 28, № 2. С. 143-150. DOI : https://doi.org/10 .21443/1560-9278-2025-28-2-143-150 Pepinsky, B., Gong, B.-J., Gao, Y., Lehmann, A. et al. 2017. A prodomain fragment from the proteolytic activation of growth differentiation factor 11 remains associated with the mature growth factor and keeps it soluble. Biochemistry, 56(33), pp. 4405-4418. DOI: https://doi.org/10.1021/acs.biochem.7b00302. Poggioli, T., Vujic, A., Yang, P., Macias-Trevino, C. et al. 2016. Circulating growth differentiation factor 11/8 levels decline with age. Circulation Research, 118(1), pp. 29-37. DOI: https://doi.org/10.1161/ CIRCRESAHA.115.307521. Qin, L., Cui, Z., Wu, Y., Wang, H. et al. 2023. Challenges and strategies to enhance the systemic absorption of inhaled peptides and proteins. Pharmaceutical Research, 40, pp. 1037-1055. DOI: https://doi.org/10.1007/ s11095-022-03435-3. Suh, J., Lee, Y.-S. 2020. Similar sequences but dissimilar biological functions of GDF11 and myostatin. Experimental &Molecular Medicine, 52, pp. 1673-1693. DOI: https://doi.org/10.1038/s12276-020-00516-4. Vandenberg, J. I., Perry, M. D., Perrin, M. J., Mann, S. A. et al. 2012. hERG K+Channels: Structure, function, and clinical significance. Physiological Reviews, 92(3), pp. 1393-1478. DOI: https://doi.org/10.1152/ physrev.00036.2011. Vita, A., De Peri, L., Deste, G., Barlati, S. et al. 2015. The effect of antipsychotic treatment on cortical gray matter changes in Schizophrenia: Does the class matter? A meta-analysis and meta-regression of longitudinal magnetic resonance imaging studies. Biological Psychiatry, 78(6), pp. 403-412. DOI: https://doi.org/ 10.1016/j.biopsych.2015.02.008. Walker, R. G., Poggioli, T., Katsimpardi, L., Buchanan, S. M. et al. 2016. Biochemistry and biology of GDF11 and myostatin: Similarities, differences, and questions for future investigation. Circulation Research, 118(7), pp. 1125-1142. DOI: https://doi.org/10.1161/CIRCRESAHA.116.308391. Wang, L., Wang, N., Zhang, W., Cheng, X. et al. 2022. Therapeutic peptides: current applications and future directions. Signal Transduction and Targeted Therapy, 7. Article number: 48. DOI: https://doi.org/10.1038/ s41392-022-00904-4. Wang, L., Wang, Y., Wang, Z., Qi, Y. et al. 2018. Growth differentiation factor 11 ameliorates experimental colitis by inhibiting NLRP3 inflammasome activation. American Journal of Physiology-Gastrointestinal and Liver Physiology , 315(6), pp. G909-G920. DOI: https://doi.org/10.1152/ajpgi.00159.2018. Watkins, P. B. 2011. Drug safety sciences and the bottleneck in drug development. Clinical Pharmacology & Therapeutics, 89(6), pp. 788-790. DOI: https://doi.org/10.1038/clpt.2011.63. Webster, J., Oxley, D. 2012. Protein identification by MALDI-TOF mass spectrometry. In Chemical Genomics and Proteomics. Eds.: E. Zanders. Humana Press, 2012. DOI: https://doi.org/10.1007/978-1-61779-349- 3_15. (Methods in Molecular Biology, vol. 800). Информация об авторах Валиева Шолпан Сергеевна - ул. Ю. А. Гагарина, 13, г. Троицк, Челябинская обл., Россия, 457103; Южно-Уральский государственный аграрный университет, аспирант; e-mail: sholpan.v85@gmail.com Sholpan S. Valieva - 13 Yu. A. Gagarin Str., Troitsk, Chelyabinsk region, Russia, 457103; South Ural State Agrarian University, PhD Student; e-mail: sholpan.v85@gmail.com Тихонов Сергей Леонидович - ул. Карла Либкнехта, 42, г. Екатеринбург, Россия, 620075; Уральский государственный аграрный университет, д-р техн. наук, профессор; Уральский государственный лесотехнический университет; e-mail: tihonov75@bk.ru, ORCID : https://orcid.org/0000-0003-4863-9834 Sergey L. Tikhonov - 42 Karl Liebknecht Str., Yekaterinburg, Russia, 620075; Ural State Agrarian University, Dr Sci. (Engineering), Professor; Ural State Forest Engineering University; e-mail: tihonov75@bk.ru, ORCID : https://orcid.org/0000-0003-4863-9834 Тихонова Наталья Валерьевна - ул. Карла Либкнехта, 42, г. Екатеринбург, Россия, 620075; Уральский государственный аграрный университет, д-р техн. наук, профессор; e-mail: tihonov75@bk.ru, ORCID : https://orcid.org/0000-0001-5841-1791 Natalya V. Tikhonova - 42 Karl Liebknecht Str., Yekaterinburg, Russia, 620075; Ural State Agrarian University, Dr Sci. (Engineering), Professor; e-mail: tihonov75@bk.ru, ORCID : https://orcid.org/0000-0001-5841-1791 149