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ВестникМГТУ, том 18, № 1, 2015 г. стр. 80-89 Исходные jo . hi : ик.шиной лепнины pH 3.4 (блокирующий поли ),inrrpuiin, linest-pohelecnvhiel хитпхана pi I 1 .1 3 4 Iлнифнлн шруюшин поли Ltckipuuui, hast’ftohvk'Clmtyte) Смешивание 20 - 30 С. юль xiiTcwauj с желатиной pll(3 2 3,4} • р| желтнны (4.7} ( 'техноиетрнчные растворииые 1био)ПЭК Эчект/ин тнпшч1ткие в lau.uvth'in пины Рис. 7. Качественная схема образования стехиометричных (био)ПЭК "желатина - хитозан" в кислой среде Литература Briones A.V., Sato Т. Ability of chitosan/carrageenan complex to encapsulate bovine serum albumin (BSA) for potential use in protein delivery. Asian Journal of Biological and Life Sciences. 2013. V. 2, N 2. P. 163-169. Derkatch S.R., Voronko N.G., Izmailova V.N. Rheological properties of gelatin gels with sodium alginate. International J. Applied Mechanics and Engineering. 2001. V. 6, N 3. P. 659-673. Gubbala S.K. Polyelectrolyte complex: A pharmaceutical review. Review Article Pharmaceutical Sciences. 2012. V. 2 .N 3 .P . 399-407. Hamman J.H. Chitosanbased polyelectrolyte complexes as potential carrier materials in drug delivery systems. Marine Drugs. 2010. V. 8. P. 1305-1322. Haug I.J., Draget K.I. Gelatin. Handbook of hydrocolloids. G.O. Phillips. P.A. Williams (Edition). Boca Raton, Boston, New York, Washington DC: CRC Press, 2009. P. 142-163. Il'ina A.V., Varlamov V.P. Chitosan-based polyelectrolyte complexes: A review. Appl. Biochem. Microbiol. 2005. V. 41. P. 5-11. Klenin V.J. Thermodynamics of systems containing flexible-chain polymers. Amsterdam, Lausanne, New York, Oxford, Shannon, Singapore, Tokyo, Elsevier, 1999. 850 p. Kramarenko E.Y., Khokhlov A.R., Reineker P. Stoichiometric polyelectrolyte complexes of ionic block copolymers and oppositely charged polyions. J. Chem. Phys. 2006. V. 125. P. 1-8. Li C., Hein S., Wang K. Chitosan - carrageenan polyelectrolyte complex for the delivery of protein drugs. Hindawi Publishing Corporation. ISRN Biomaterials. 2013. V. 2013. P. 1-6. Mitsumata T. et al. pH-response of chitosan, к-carrageenan, carboxymethyl cellulose sodium salt complex hydrogels. Polymer. 2003. V. 44. P. 7103-7111. Muzzarelli R.A.A., Muzzarelli C. Chitin and chitosan hydrogels. Handbook of hydrocolloids. G.O. Phillips. P.A. Williams (Edition). Boca Raton, Boston, New York, Washington DC, CRC Press, 2009. P. 849-888. Patel M.P., Patel R.R., Patel J.K. Chitosan mediated targeted drug delivery system: A Review. J. Pharm. Pharmaceut. Sci. 2010. V. 13, N 3. P. 536-557. 87